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​사람을 생각하는 연구, 미래를 발전시킬 동력

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재생의학 전문연구인력 양성 교육팀

​한양대학교 의생명공학전문대학원 의생명과학과

4단계 BK21 사업 소개 (Brain Korea 21 FOUR)

 

  • 본 사업팀은 미래 국가경쟁력 제고를 위하여 재생의학 분야 전문연구인력 양성 및 학문후속세대 양성을 추진하기 위한 사업.

  • 생명공학, 의학의 융복합적 학제를 기반으로 하여 재생의학의 사회적 요구를 충족하고 이를 응용하여 난치성 질환 극복 연구에 적합한 전문인력 양성을 지향.

  • 다양한 연구를 통한 목표를 달성을 위하여 깊이 있고 두터운 학문적 후속세대 양성.

Archives

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Latest Publications

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling

Adult human cardiomyocytes have an extremely limited proliferative capacity, which poses a great barrier to regenerative medicine and research. Human embryonic stem cells (hESCs) have been proposed as an alternative source to generate large numbers of clinical grade cardiomyocytes (CMs) that can have potential therapeutic applications to treat cardiac diseases. Previous studies have shown that bioactive lipids are involved in diverse cellular responses including cardiogenesis. In this study, we explored the novel function of the chemically synthesized bioactive lipid O-cyclic phytosphingosine-1-phosphate (cP1P) as an inducer of cardiac differentiation. Here, we identified cP1P as a novel factor that significantly enhances the differentiation potential of hESCs into cardiomyocytes. Treatment with cP1P augments the beating colony number and contracting area of CMs. Furthermore, we elucidated the molecular mechanism of cP1P regulating SMAD1/5/8 signaling via the ALK3/BMP receptor cascade during cardiac differentiation. Our result provides a new insight for cP1P usage to improve the quality of CM differentiation for regenerative therapies.

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